Fighting Fire with Fire: Development of Intranasal Nalmefene to Treat Synthetic Opioid Overdose

Time: 6:00 pm
day: Day One


  • Synthetic opioids like fentanyl now drive the opioid epidemic, responsible for more overdose deaths than both heroin and prescription opioids
  • Nalmefene is a potent, long acting opioid antagonist; these properties make it especially well-suited to treat overdose caused by synthetic opioids
  • OPNT 003 is a proprietary formulation of nalmefene nasal spray. The pharmacokinetic properties (Cmax and tmax) of OPNT 003 indicate its onset of action is faster than an intramuscular dose of nalmefene previously approved to treat overdose
  •  Defining the path towards filing a New Drug Application (NDA) for this product in 2020